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Clinical Trial
. 1976 Aug;34(2):174-9.
doi: 10.1038/bjc.1976.140.

Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma

E S Newlands, C J Oon, J T Roberts, P Elliott, R F Mould, C Topham, F J Madden, K A Newton, G Westbury
Free PMC article
Clinical Trial

Clinical trial of combination chemotherapy and specific active immunotherapy in disseminated melanoma

E S Newlands et al. Br J Cancer. 1976 Aug.
Free PMC article

Abstract

Fifty-six patients with disseminated malignant melanoma were randomly allocated to two treatment groups. The first group C received combination chemotherapy consisting of DTIC and ICRF 159. The second group (C+I) received the same chemotherapy but were also immunized with 2 X 10(7) irradiated allogeneic melanoma cells mixed with 50 mug of percutaneous BCG. The survival rates in both treatment groups C and (C+I) were not significantly different, and only minor enhancement of the chemotherapy was found in the (C+I) group. A similar pattern of tissue response was observed in both groups: lymph node, skin and, to some extent liver metastases, respond better than other sites.

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References

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