Diagnosis of sickle-cell disease by DNA analysis in Nigeria
- PMID: 9631113
Diagnosis of sickle-cell disease by DNA analysis in Nigeria
Abstract
Objective: To compare genotyping of leucocyte DNA by PCR and Dde I with the conventional genotyping of haemoglobin of the same subject.
Design: Comparative study.
Subjects: 25 adults, 16 males and nine females.
Main outcome measures: Predictability.
Results: In all cases the results were comparable.
Conclusions: The technology can be applied locally to prenatal diagnosis of sickle-cell disease by chorionic sampling and, therefore, improve the management of sickle-cell disease in Nigeria.
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