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Case Reports
. 1998 Feb;67(2):199-203.
doi: 10.1016/s0925-5710(97)00110-2.

Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

K Kojima  1 , M Taniwaki, T Yoshino, Y Katayama, K Sunami, S Fukuda, E Omoto, M Harada, T Sezaki
Affiliations
Case Reports

Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

K Kojima et al. Int J Hematol. 1998 Feb.

Abstract

We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cell with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL.

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