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. 1976 Oct;16(10):1201-38.
doi: 10.1016/S0006-3495(76)85768-2.

Prediction of the conformation of the histones

Prediction of the conformation of the histones

G D Fasman et al. Biophys J. 1976 Oct.

Abstract

The secondary structures of the histones, H1, H2A, H2B, H3, and H4 have been predicted utilizing the predictive scheme of Chou and Fasman (Biochemistry 13:211, 222[1974]) and a new set of conformational parameters based on the X-ray data of 29 protein structures. The alpha-helical, beta-sheet, reverse beta-turns, and random coil regions of these proteins are carefully delineated. Structures are specified which are most probably under various environmental conditions, i.e., for changes in ionic strength, association between histones and in association with DNA. Potential conformational changes within these histones are also predicted.

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References

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