Malignant cold thyroid nodules in hyperthyroidism

Abstract

In 65 hyperthyroid patients with a cold nodule a carcinoma was found at operation in 14 cases, i.e. a malignancy incidence of 21-5 per cent. In 859 euthyroid cases with a cold thyroid nodule 104 malignant lesions (12-1 per cent) were found. The difference is statistically significant. Surgery in cases with a cold thyroid nodule is strongly indicated if this occurs in a hyperthyroid gland.