Review
doi: 10.1016/s0969-2126(98)00056-2.
Teaching a new dog old tricks?
Affiliations
- PMID: 9634692
- DOI: 10.1016/s0969-2126(98)00056-2
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Review
Teaching a new dog old tricks?
Structure.
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Free article
Abstract
The recently determined crystal structures of fragments of the human and vaccinia virus type IB topoisomerases reveal unexpected similarity with the lambda family of site-specific recombinases. The conservation of structure suggests a common mechanism, indicating that topoisomerase activity may be the consequence of uncoupling DNA strand cleavage/religation from synapsis.
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