Review
doi: 10.1016/s0952-7915(98)80170-2.
Negative regulation of T cell activation
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- PMID: 9638368
- DOI: 10.1016/s0952-7915(98)80170-2
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Review
Negative regulation of T cell activation
Curr Opin Immunol.
1998 Jun.
Abstract
T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based activation motifs and tyrosine kinases, inhibitory signals are delivered by tyrosine phosphatases. Unresponsiveness is also induced by modulation of signaling components of the T cell receptor complex.
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