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. 1976 Jul;6(4):373-81.
doi: 10.1111/j.1365-2222.1976.tb01919.x.

The relationship between bronchial histamine reactivity and atopic status

D H Bryant, M W Burns

The relationship between bronchial histamine reactivity and atopic status

D H Bryant et al. Clin Allergy. 1976 Jul.

Abstract

It has been proposed that increased production of IgE, a feature of atopy, is a cause of the non-specific bronchial hyper-reactivity that is characterisitc of asthma. This hypothesis was examined by selecting groups of subjects with asthma or rhinitis and a group of healthy control subjects and studying the relationship between their bronchial histamine reactivity and their atopic status. In none of the groups tested was there a significant association between the degree of bronchial histamine reactivity and either the serum level of total IgE or the number of extracts of aeroallergens giving positive prick test reactions.

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