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. 1998 Mar;57(3):152-7.
doi: 10.1136/ard.57.3.152.

Quantitative assessment of the rheumatoid synovial microvascular bed by gadolinium-DTPA enhanced magnetic resonance imaging

K Gaffney  1 , J Cookson, S Blades, A Coumbe, D Blake
Affiliations

Quantitative assessment of the rheumatoid synovial microvascular bed by gadolinium-DTPA enhanced magnetic resonance imaging

K Gaffney et al. Ann Rheum Dis. 1998 Mar.

Abstract

Objective: To examine the relation between rate of synovial membrane enhancement, intra-articular pressure (IAP), and histologically determined synovial vascularity in rheumatoid arthritis, using gadolinium-DTPA enhanced magnetic resonance imaging (MRI).

Methods: Dynamic gadolinium-DTPA enhanced MRI was performed in 31 patients with knee synovitis (10 patients IAP study, 21 patients vascular morphometry study). Rate of synovial membrane enhancement was quantified by line profile analysis using the image processing package ANALYZE. IAP was measured using an intra-compartmental pressure monitor system. Multiple synovial biopsy specimens were obtained by a blind biopsy technique. Blood vessels were identified immunohistochemically using the endothelial cell marker QBend30 and quantified (blood vessel numerical density and fractional area).

Results: Median blood vessel numerical density and fractional area were 77.5/mm2 (IQR; 69.3-110.7) and 5.6% (IQR; 3.4-8.5) respectively. The rate of synovial membrane enhancement (median 2.74 signal intensity units/s, IQR 2.0-3.8) correlated with both blood vessel numerical density (r = 0.46, p < 0.05) and blood vessel fractional area (r = 0.55, p < 0.02). IAP did not influence the rate of enhancement.

Conclusions: Gadolinium-DTPA enhanced MRI may prove to be a valuable technique for evaluating drugs that influence angiogenesis.

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Figures

Figure 1
Figure 1
Sagittal section through a rheumatoid knee joint before and after intravenous administration of gadolinium-DTPA.
Figure 2
Figure 2
Relation between rate of synovial membrane enhancement and resting intra-articular pressure.
Figure 3
Figure 3
Relation between rate of synovial membrane enhancement and volume of synovial fluid aspirated.
Figure 4
Figure 4
Rheumatoid synovial microvascular endothelium identified immunohistochemically by QBend 30.
Figure 5
Figure 5
Relation between rate of synovial membrane enhancement and blood vessel numerical density.
Figure 6
Figure 6
Relation between rate of synovial membrane enhancement and blood vessel fractional area.
See this image and copyright information in PMC

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