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Comparative Study
. 1998 Jun 26;61(6):729-33.
doi: 10.1021/np970433o.

Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga

K Murata  1 , F Takano, S Fushiya, Y Oshima
Affiliations
Comparative Study

Enhancement of NO production in activated macrophages in vivo by an antimalarial crude drug, Dichroa febrifuga

K Murata et al. J Nat Prod. .

Abstract

The effect of an antimalarial crude drug, Dichroafebrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guérin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.

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