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Review
. 1998;99(4):221-3.
doi: 10.1159/000040843.

Coexistence of chronic myelogenous leukemia and multiple myeloma. Case report and review of the literature

M Tanaka  1 , R Kimura, A Matsutani, K Zaitsu, Y Oka, K Oizumi
Affiliations
Review

Coexistence of chronic myelogenous leukemia and multiple myeloma. Case report and review of the literature

M Tanaka et al. Acta Haematol. 1998.

Abstract

A case report of simultaneous presentation of chronic myelogenous leukemia (CML) and multiple myeloma (MM) in a 72-year-old female is described. Our case was typical of Ph1-positive and chimeric bcr-abl messenger RNA-positive CML. Furthermore, a marked IgG (kappa-type) paraproteinemia was present. Fluorescence in situ hybridization showed that 97% of marrow nucleated cells were positive for bcr-abl fusion signal, when myeloma cells in the bone marrow amounted to 19.0%. In the literature survey, 4 similar cases with coexistence of CML and MM have been identified.

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