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Review
. 1998 Jun;23(6):217-21.
doi: 10.1016/s0968-0004(98)01219-5.

Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase

M J Warren  1 , J B Cooper, S P Wood, P M Shoolingin-Jordan
Affiliations
Review

Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase

M J Warren et al. Trends Biochem Sci. 1998 Jun.

Abstract

In mammals and yeast, 5-aminolaevulinic acid dehydratase is a zinc-dependent enzyme that catalyses the synthesis of porphobilinogen-the pyrrole building block that is incorporated into all modified tetrapyrroles, including haem, chlorophyll and vitamin B12. The X-ray structure of this enzyme reveals how substitution of the catalytically important zinc ion by lead inactivates the enzyme and causes a form of pseudo-porphyria.

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