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. 1978 Apr 14;57(1):39-42.
doi: 10.1007/BF00426955.

Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward

R J Katz, B J Carroll
Free article

Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward

R J Katz et al. Psychopharmacology (Berl). .
Free article

Abstract

The centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C. 2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rats of responding for rewarding brain stimulation in adult male rats. Decreases occurred at dosages that did not produce measurable neurologic impairment. This suggests a possible role for central epinephrine-containing neurons in the maintenance of reward-mediated behaviors.

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