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Comparative Study
. 1998 Jul;75(1):174-82.
doi: 10.1016/S0006-3495(98)77504-6.

Evidence for a novel bursting mechanism in rodent trigeminal neurons

C A Del Negro  1 , C F Hsiao, S H Chandler, A Garfinkel
Affiliations
Comparative Study

Evidence for a novel bursting mechanism in rodent trigeminal neurons

C A Del Negro et al. Biophys J. 1998 Jul.

Abstract

We investigated bursting behavior in rodent trigeminal neurons. The essential mechanisms operating in the biological systems were determined based on testable predictions of mathematical models. Bursting activity in trigeminal motoneurons is consistent with a traditional mechanism employing a region of negative slope resistance in the steady-state current-voltage relationship (Smith, T. G. 1975. Nature. 253:450-452). However, the bursting dynamics of trigeminal interneurons is inconsistent with the traditional mechanisms, and is far more effectively explained by a new model of bursting that exploits the unique stability properties associated with spike threshold (Baer, S. M., T. Erneux, and J. Rinzel. 1989. SIAM J. Appl. Math. 49:55-71).

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