Is the decline in renal function with normal aging inevitable?

Abstract

The structural changes observed in the normal aging kidney support a concept that one should expect a decline in renal function as one ages. Reports by renal physiologists, however, suggest that this is not always true. The suggestion is made that vascular adaptations to structural changes may help to preserve glomerular filtration rate by producing a state of hyperperfusion and hyperfiltration in surviving nephrons.