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. 1976;51(4):416-28.
doi: 10.1159/000231616.

Characteristics of guinea pig IgE

Z Ovary, B Kaplan, S Kojima

Characteristics of guinea pig IgE

Z Ovary et al. Int Arch Allergy Appl Immunol. 1976.

Abstract

Anti-dinitrophenyl (DNP) IgE antibody was produced in guinea pigs (GP) by immunization and repeated boosters with 1 mug DNP-Ascaris extract in A1 (OH)3. The isoelectric point was determined to be 6.48 and the molecular weight to be 185,000 daltons. In absorbtion chromatography, rabbit anti-GPIgG1 could not absorb the anaphylactic activity of the IgE. The activity of IgE was destroyed by heating at 56 degrees C for 1 h. IgE persisted in the skin for at least 3 weeks.

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