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Comparative Study
. 1998 May 8;709(1):57-67.
doi: 10.1016/s0378-4347(98)00018-8.

Determination of ropivacaine and [2H3]ropivacaine in biological samples by gas chromatography with nitrogen-phosphorus detection or mass spectrometry

M Engman  1 , P Neidenström, C Norsten-Höög, S J Wiklund, U Bondesson, T Arvidsson
Affiliations
Comparative Study

Determination of ropivacaine and [2H3]ropivacaine in biological samples by gas chromatography with nitrogen-phosphorus detection or mass spectrometry

M Engman et al. J Chromatogr B Biomed Sci Appl. .

Abstract

Bioanalytical methods for determining the total concentration of the new local anaesthetic drug ropivacaine in blood plasma, urine and tissues are presented. Ropivacaine is a drug mainly used in connection with surgery and for post-operative pain relief. The biological samples were prepared using liquid-liquid extraction and analysed using capillary gas chromatography with nitrogen-phosphorus detection or mass spectrometry. The methods are highly selective and reliable with a between-day precision, given as the relative standard deviation, generally below 6%. More than 20000 samples have been analysed using the methods described.

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