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. 1998 Jun;79(6):1166-70.

Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy

P Clark  1 , J Brennand, J A Conkie, F McCall, I A Greer, I D Walker
Affiliations
  • PMID: 9657443

Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy

P Clark et al. Thromb Haemost. 1998 Jun.

Abstract

A prospective study of activated protein C sensitivity, protein C, protein S, and other coagulation factors in 239 women during normal pregnancy was carried out. Protein C activity appeared unaffected by gestation, although an elevation of protein C activity was observed in the early puerperium. A fall in total and free protein S with increasing gestation was observed. Activated protein C sensitivity ratio (APC:SR) showed a progressive fall through pregnancy. This fall correlated with changes in factor VIIIc, factor Vc and protein S. 38% of subjects, with no evidence of Factor V Leiden or anticardiolipin antibodies, showed a low APC:SR (APC:SR <2.6) in the third trimester of pregnancy. Aside from a significant reduction in birth weight, no difference in pregnancy outcome was observed between these subjects and those with a normal APC:SR. Activated protein C sensitivity ratio, modified by pre-dilution of patient samples with factor V depleted plasma, showed no consistent trend with gestation.

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