doi: 10.1111/j.1744-313x.1976.tb00573.x.
Genetic control of the immune response to ferritin in mice
- PMID: 965768
- DOI: 10.1111/j.1744-313x.1976.tb00573.x
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Genetic control of the immune response to ferritin in mice
J Immunogenet.
1976 Jun.
Abstract
The immune response to the antigen horse spleen ferritin was tested in sixteen inbred strains of mice. Using a fixed antigen percentage bound isotope technique, it was found that the quantity of antibody produced was related to the genetic status of the responding animal. A continuous distribution of responses was obtained, which were found to be linked to H-2 loci and the 2 non-H-2 loci 'Tla' and 'Theta' and these responses are detectable following primary immunization. It is suggested that the continuous distribution of quantitative antibody responses to ferritin, is compatible either with a large number of IR-genes or with a cross tolerance hypothesis requiring no IR-genes at all.
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