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. 1998 Aug;72(8):6929-31.
doi: 10.1128/JVI.72.8.6929-6931.1998.

Viral determinants of rotavirus pathogenicity in pigs: evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host

J C Bridger  1 , G I Tauscher, U Desselberger
Affiliations

Viral determinants of rotavirus pathogenicity in pigs: evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host

J C Bridger et al. J Virol. 1998 Aug.

Abstract

A porcine rotavirus (prv) monoreassortant, S-F4, which carries RNA segment 4 of the pig-pathogenic variant prv 4F in the genetic background of the pig-apathogenic variant prv 4S (G. I. Tauscher and U. Desselberger, J. Virol. 71:853-857, 1997), was found to be pathogenic in gnotobiotic piglets. This indicates that RNA segment 4 of the pig-pathogenic variant prv 4F is a major determinant of pathogenicity in its homologous host.

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Figures

FIG. 1
FIG. 1
Daily weights (in kilograms) of representative piglets inoculated with S-F4 (▪), prv 4F (✻), and prv 4S (•), and of a sham-inoculated piglet (▴), at the third serial passage of the viruses.
See this image and copyright information in PMC

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