Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 May;78(5):408-12.
doi: 10.1136/adc.78.5.408.

A prospective 10 year follow up study of patients with neurofibromatosis type 1

M H Cnossen  1 , A de Goede-Bolder, K M van den Broek, C M Waasdorp, A P Oranje, H Stroink, H J Simonsz, A M van den Ouweland, D J Halley, M F Niermeijer
Affiliations

A prospective 10 year follow up study of patients with neurofibromatosis type 1

M H Cnossen et al. Arch Dis Child. 1998 May.

Abstract

Objective: To establish the prevalence and incidence of symptoms and complications in children with neurofibromatosis type 1 (NF1) and to assess possible risk factors for the development of complications.

Design: A 10 year prospective multidisciplinary follow up study.

Patients: One hundred and fifty children diagnosed with NF1 according to criteria set by the National Institutes of Health.

Results: In 62 of 150 children (41.3%) complications were present, including 42 (28.0%) children with one complication, 18 (12.0%) with two complications, and two (1.3%) with three complications (mean (SD) duration of follow up 4.9 (3.8) years). Ninety five of the 150 children presented without complications (follow up, 340.8 person-years). The incidence of complications was 2.4/100 person-years in this group. An association was found between behavioural problems and the presence of complications.

Conclusion: This is the largest single centre case series of NF1 affected children followed until 18 years of age. Children with NF1, including those initially presenting without complications, should have regular clinical examinations.

PubMed Disclaimer

References

    1. Childs Brain. 1983;10(2):99-111 - PubMed
    1. Am J Dis Child. 1989 Jun;143(6):717-9 - PubMed
    1. J Med Genet. 1989 Nov;26(11):704-11 - PubMed
    1. J Pediatr. 1994 Jul;125(1):63-6 - PubMed
    1. J Pediatr. 1992 Oct;121(4):584-7 - PubMed