[Microsomal oxygenase enzyme system during chronic administration of 2-acetylaminofluorene]
[Article in
Russian]
- PMID: 96595
Item in Clipboard
[Microsomal oxygenase enzyme system during chronic administration of 2-acetylaminofluorene]
[Article in
Russian]
Vopr Med Khim.
1978 Jan-Feb.
Abstract
Alteration in content of enzymatic components was studied in microsomal oxygenases system of rats administered with 2-acetyl aminofluorene. Content of cytochrome R-450 was decreased beginning from the fourth week of the experiment. Activity of NADP cytochrome c reductase was higher in animals, treated with the drug as compared with controls. Inductors of the I and II type were capable to induce the enzymatic system up to the end of the experiment - within 16 weeks as far as liver tumors developed.
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