Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Feb;1(3):359-69.
doi: 10.1016/s1097-2765(00)80036-2.

Identification of a tRNA-specific nuclear export receptor

U Kutay  1 , G Lipowsky, E Izaurralde, F R Bischoff, P Schwarzmaier, E Hartmann, D Görlich
Affiliations
Free article

Identification of a tRNA-specific nuclear export receptor

U Kutay et al. Mol Cell. 1998 Feb.
Free article

Abstract

In eukaryotes, tRNAs are synthesized in the nucleus and after several maturation steps exported to the cytoplasm. Here, we identify exportin-t as a specific mediator of tRNA export. It is a RanGTP-binding, importin beta-related factor with predominantly nuclear localization. It shuttles rapidly between nucleus and cytoplasm and interacts with nuclear pore complexes. Exportin-t binds tRNA directly and with high affinity. Its cellular concentration in Xenopus oocytes was found to be rate-limiting for export of all tRNAs tested, as judged by microinjection experiments. RanGTP regulates the substrate-exportin-t interaction such that tRNA can be preferentially bound in the nucleus and released in the cytoplasm.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources