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. 1998 Mar;1(4):507-18.
doi: 10.1016/s1097-2765(00)80051-9.

Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo

M G Wathelet  1 , C H Lin, B S Parekh, L V Ronco, P M Howley, T Maniatis
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Free article

Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo

M G Wathelet et al. Mol Cell. 1998 Mar.
Free article

Erratum in

  • Mol Cell 1999 Jun;3(6):813

Abstract

We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon regulatory factor (IRF) family of transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-beta) gene promoter in vitro. However, in virus-infected cells, both proteins are recruited to the endogenous IFN-beta promoter as part of a protein complex that includes ATF-2/c-Jun and NF-kappa B. These observations provide a unique example of the coordinate activation of multiple transcriptional activator proteins and their highly cooperative assembly into a transcriptional enhancer complex in vivo.

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