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Review
. 1998 Jul;42(7):1529-36.
doi: 10.1128/AAC.42.7.1529.

Two-component signal transduction as a target for microbial anti-infective therapy

J F Barrett  1 , J A Hoch
Affiliations
Review

Two-component signal transduction as a target for microbial anti-infective therapy

J F Barrett et al. Antimicrob Agents Chemother. 1998 Jul.
No abstract available

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Figures

FIG. 1
FIG. 1
Typical two-component signal transduction system.
FIG. 2
FIG. 2
Simple example of some principles of networking in two-component signal transduction.
FIG. 3
FIG. 3
Chemical structures of the antialginate two-component kinase inhibitors. More than 95% of algD promoter inhibition activity was observed for inhibitors 1 and 2 at 2 to 2.5 μg/ml. Compounds 1 and 3 also inhibit AlgR1, whereas compounds 2 and 4 do not, but compounds 2 and 4 do inhibit other kinases (66, 67).
FIG. 4
FIG. 4
Prototypical structures of diphenolic methanes with NRII inhibitory activity and weak activity against gram-positive bacteria (19).
FIG. 5
FIG. 5
Prototypical structures from the efforts of the R. W. Johnson Pharmaceutical Research Institute. These five series represent the reported inhibitors in a variety of in vitro, microbiological, and in vivo test systems (27, 47, 48, 52, 62, 79, 87, 88, 91).
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