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Clinical Trial
. 1998 Jul;42(7):1578-80.
doi: 10.1128/AAC.42.7.1578.

Oral cimetidine prolongs clarithromycin absorption

G W Amsden  1 , K L Cheng, C A Peloquin, A N Nafziger
Affiliations
Free PMC article
Clinical Trial

Oral cimetidine prolongs clarithromycin absorption

G W Amsden et al. Antimicrob Agents Chemother. 1998 Jul.
Free PMC article

Abstract

The present study was conducted to identify any potential interaction between oral cimetidine and clarithromycin. Twelve healthy subjects were administered single doses of clarithromycin alone and with oral cimetidine dosed to steady state. Cimetidine prolonged the absorption of clarithromycin, as evidenced by decreased peak concentrations of both clarithromycin and 14-OH-clarithromycin (14OHC) in serum (46 and 43%, respectively), a delay in the formation of 14OHC (increase of 68%), and increases in both of their half-lives (75 and 82%, respectively), despite no changes in total oral clearance or area under the concentration-time curve for either compound. No mechanism for this interaction has been identified.

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Figures

FIG. 1
FIG. 1
Serum clarithromycin concentrations versus time with (formula image) and without (⧫) cimetidine.
FIG. 2
FIG. 2
Serum 14OHC concentrations versus time with (formula image) and without (⧫) cimetidine.
See this image and copyright information in PMC

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