Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury
- PMID: 9662372
- DOI: 10.1038/nm0798-808
Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury
Abstract
The mechanism of immunodepression after brain injury is not yet clear. Here we demonstrate rapid systemic release of the immunoinhibitory cytokine interleukin-10, monocytic deactivation and a high incidence of infection in patients with 'sympathetic storm' due to acute accidental or iatrogenic brain trauma. In vitro studies showed that within minutes catecholamines trigger the secretion of interleukin-10 from unstimulated monocytes through a beta-adrenoreceptor-mediated, cAMP/protein kinase A-dependent pathway. We found that in a rat model of acute brain injury, the beta-receptor antagonist propranolol prevented the increase of interleukin-10 plasma levels. Rapid monocytic interleukin-10 release after sympathetic activation may represent a common pathway for immunodepression induced by stress and injury.
Comment in
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Brain injury and immunosuppression.Nat Med. 1998 Jul;4(7):768-9. doi: 10.1038/nm0798-768. Nat Med. 1998. PMID: 9662362 No abstract available.
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