Ribozymes: the hammerhead swings into action
- PMID: 9663384
- DOI: 10.1016/s0960-9822(98)70316-1
Ribozymes: the hammerhead swings into action
Abstract
A new crystal structure of a modified hammerhead ribozyme reveals an intermediate conformation that may explain discrepancies between previous structures and the required orientation of the labile bond in the ribozyme's active site.
Similar articles
-
The hammerhead ribozyme: structure, catalysis, and gene regulation.Prog Mol Biol Transl Sci. 2013;120:1-23. doi: 10.1016/B978-0-12-381286-5.00001-9. Prog Mol Biol Transl Sci. 2013. PMID: 24156940 Free PMC article. Review.
-
Replacement of the phosphodiester bond between U4 and G5 in the U-turn of a chemically modified hammerhead ribozyme by an amide bond.Nucleosides Nucleotides Nucleic Acids. 2000 Apr;19(4):749-56. doi: 10.1080/15257770008035022. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 10960033
-
Capturing hammerhead ribozyme structures in action by modulating general base catalysis.PLoS Biol. 2008 Sep 30;6(9):e234. doi: 10.1371/journal.pbio.0060234. PLoS Biol. 2008. PMID: 18834200 Free PMC article.
-
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.J Am Chem Soc. 2019 May 15;141(19):7865-7875. doi: 10.1021/jacs.9b02141. Epub 2019 May 2. J Am Chem Soc. 2019. PMID: 31017785 Free PMC article.
-
Hammerhead ribozyme structure: U-turn for RNA structural biology.Structure. 1995 Aug 15;3(8):747-50. doi: 10.1016/s0969-2126(01)00208-8. Structure. 1995. PMID: 7582890 Review.
Cited by
-
Recent advances in the elucidation of the mechanisms of action of ribozymes.Nucleic Acids Res. 2001 May 1;29(9):1815-34. doi: 10.1093/nar/29.9.1815. Nucleic Acids Res. 2001. PMID: 11328865 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources