Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Jul;11(3):514-32.
doi: 10.1128/CMR.11.3.514.

Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis

A Glatman-Freedman  1 , A Casadevall
Affiliations
Review

Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis

A Glatman-Freedman et al. Clin Microbiol Rev. 1998 Jul.

Abstract

Fifty years after the introduction of the first effective antimicrobial agents against Mycobacterium tuberculosis, this pathogen continues to be a tremendous public health problem. The rise in the number of resistant strains and the difficulties involved in the therapy of tuberculosis in immunocompromised AIDS patients have renewed the interest in the development of effective vaccines. To evaluate whether a potential vaccine against tuberculosis could prevent infection by eliciting a protective antibody response, we reviewed the history of antibody-mediated immunity against tuberculosis. Review of the literature of the past 100 years demonstrates that there is sufficient evidence to conclude that antibody-mediated immunity can modify the course of infection in certain situations. Based on our findings and on what is known in other systems, we propose that the role of antibody-mediated immunity to M. tuberculosis be reexamined, using advanced technology.

PubMed Disclaimer

References

    1. Andersen A B, Brennan P J. Proteins and antigens of Mycobacterium tuberculosis. In: Bloom B R, editor. Tuerculosis. Pathogenesis, protection and control. Washington, D.C: ASM Press; 1994. pp. 307–332.
    1. Andersen P. Host responses and antigens involved in protective immunity to Mycobacterium tuberculosis. Scand J Immunol. 1997;45:115–131. - PubMed
    1. Anonymous. The results obtained by Dr. Viquerat in his treatment of tuberculosis. Lancet. 1894;ii:756–757.
    1. Armstrong J A, Hart P D. Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. J Exp Med. 1975;142:1–16. - PMC - PubMed
    1. Band H, Sinha S, Talwar G P. Inhibition of interaction of mycobacteria with Schwann cells by antimycobacterial antibodies. J Neuroimmunol. 1987;14:235–239. - PubMed

Publication types

LinkOut - more resources