Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Aug;36(8):2353-5.
doi: 10.1128/JCM.36.8.2353-2355.1998.

In vitro testing of susceptibilities of filamentous ascomycetes to voriconazole, itraconazole, and amphotericin B, with consideration of phylogenetic implications

M R McGinnis  1 , L Pasarell
Affiliations

In vitro testing of susceptibilities of filamentous ascomycetes to voriconazole, itraconazole, and amphotericin B, with consideration of phylogenetic implications

M R McGinnis et al. J Clin Microbiol. 1998 Aug.

Abstract

The in vitro susceptibilities of three hundred eighty-one isolates representing two classes, five orders, nine families, 30 genera, and 51 species of ascomycetous fungi to voriconazole, itraconazole, and amphotericin B were tested by using a modification of the National Committee for Clinical Laboratory Standards M27-A reference method. For those fungi of known phylogenetic relatedness, drug MICs were consistently low for isolates among all clades, except for members of the family Microascaceae. The highest MICs of all drugs tested were consistently for the Microascaceae, supporting the observation of fungal phylogeny and corresponding susceptibility to antifungal drugs. Itraconazole and voriconazole have a broad range of activity against phylogenetically similar agents of hyalohyphomycosis, phaeohyphomycosis, chromoblastomycosis, and mycetoma.

PubMed Disclaimer

References

    1. Alilou M. Madurella grisea est-il synonyme de Pyrenochaeta romeroi? Bull Soc Mycol Med. 1977;6:227–230.
    1. Barry A L, Brown S D. In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species. Antimicrob Agents Chemother. 1996;40:1948–1949. - PMC - PubMed
    1. Espinel-Ingroff A. In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens. J Clin Microbiol. 1998;36:198–202. - PMC - PubMed
    1. Marco F, Pfaller M A, Messer S, Jones R N. In vitro activities of voriconazole (UK-109,496) and four other antifungal agents against 394 clinical isolates of Candida spp. Antimicrob Agents Chemother. 1998;42:161–163. - PMC - PubMed
    1. McGinnis M R, Pasarell L, Sutton D A, Fothergill A W, Cooper C R, Jr, Rinaldi M G. In vitro evaluation of voriconazole against some clinically important fungi. Antimicrob Agents Chemother. 1997;41:1832–1834. - PMC - PubMed

Publication types

LinkOut - more resources