Desperately seeking subunits: are native 5-HT3 receptors really homomeric complexes?
- PMID: 9666711
- DOI: 10.1016/s0165-6147(98)01210-3
Desperately seeking subunits: are native 5-HT3 receptors really homomeric complexes?
Abstract
The 5-HT3 receptor complex is a ligand-gated ion channel, and is therefore likely to comprise multiple subunits in common with other members of this superfamily. To date, however, only one 5-HT3 receptor subunit, plus an alternatively spliced variant, have been identified. In this article, Stephanie Fletcher and Nicholas Barnes review some of the extensive data in the literature that suggest the presence of other 5-HT3 receptor subunits. This is particularly relevant given the recent demonstration that the 5-HT3 receptor purified from pig brain contains a non-5-HT3A-like protein(s).
Similar articles
-
The 5-HT3B subunit is a major determinant of serotonin-receptor function.Nature. 1999 Jan 28;397(6717):359-63. doi: 10.1038/16941. Nature. 1999. PMID: 9950429
-
Purification of 5-hydroxytryptamine3 receptors from porcine brain.Br J Pharmacol. 1997 Oct;122(4):655-62. doi: 10.1038/sj.bjp.0701439. Br J Pharmacol. 1997. PMID: 9375961 Free PMC article.
-
The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.J Physiol. 2000 Jan 15;522 Pt 2(Pt 2):187-98. doi: 10.1111/j.1469-7793.2000.00187.x. J Physiol. 2000. PMID: 10639097 Free PMC article.
-
The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review).Mol Membr Biol. 2002 Jan-Mar;19(1):11-26. doi: 10.1080/09687680110110048. Mol Membr Biol. 2002. PMID: 11989819 Review.
-
5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic.Neurochem Int. 1999 Aug;35(2):125-30. doi: 10.1016/s0197-0186(99)00054-6. Neurochem Int. 1999. PMID: 10405996 Review.
Cited by
-
Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization.J Physiol. 2002 Nov 1;544(3):715-26. doi: 10.1113/jphysiol.2002.029736. J Physiol. 2002. PMID: 12411518 Free PMC article.
-
Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor.Biophys J. 2003 Mar;84(3):1720-33. doi: 10.1016/S0006-3495(03)74980-7. Biophys J. 2003. PMID: 12609874 Free PMC article.
-
Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.J Comp Neurol. 2011 Feb 15;519(3):420-32. doi: 10.1002/cne.22525. J Comp Neurol. 2011. PMID: 21192076 Free PMC article.
-
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.Neuropsychopharmacology. 2010 Jun;35(7):1510-9. doi: 10.1038/npp.2010.20. Epub 2010 Mar 3. Neuropsychopharmacology. 2010. PMID: 20200506 Free PMC article.
-
Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors.PLoS One. 2009 Aug 21;4(8):e6715. doi: 10.1371/journal.pone.0006715. PLoS One. 2009. PMID: 19696922 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources