Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Jun;1(1):10-6.
doi: 10.1016/s1367-5931(97)80103-2.

The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets

B E Eaton  1
Affiliations
Review

The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets

B E Eaton. Curr Opin Chem Biol. 1997 Jun.

Abstract

Oligonucleotide in vitro selection provides surprisingly specific aptamers to protein targets. Synthetic chemistries for modifying nucleotides have been developed to enhance aptamer binding affinity. The diversity of nucleosides amenable to either triphosphate synthesis or phosphoramidite activation is now sufficiently broad to rival any oligomeric combinatorial library.

PubMed Disclaimer

Publication types

LinkOut - more resources