The studies on neurogenesis induced by brain injury in adult ring dove

Abstract

It was the first time demonstrated by us that the number of newborn neurons was increased after making lesion in forebrain of adult ring dove (Streptopelia risoria) by means of autoradiography and immunohistochemistry. Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrolytic lesion of nucleus ectostriatum (E), the mean number of proliferating cells in the lateral ventricular zone (LVZ) and newborn neurons in the forebrain increased by 1.95 times and 2.38 times respectively as compared with that in intact doves. The most remarkable increase of neurogenesis induced by nucleus ectostriatum lesions was found at the anterior-posterior level 3 (L3), where the lesion site was located. These results showed that the electrolytic brain lesion altered the distribution pattern of proliferating cells in the LVZ and resulted in increase of the number of newborn neurons in the non-VZ areas of forebrain. The changes in number and distribution pattern of proliferating cells in LVZ and newborn neurons in forebrain may be dependent on site of lesion. Studies on the relationship between proliferating cells in LVZ and newly generated neurons in non-VZ areas may help to understand the mechanism of brain plasticity and development.