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. 1978 May;27(5):223-7.

Incremental intravenous nitroglycerin for control of afterload during anesthesia in patients undergoing myocardial revascularization

K B Stengert, B L Wilsey, E J Hurley, T M Grehl, A J Lurie, R C Klein, L R Upjohn
  • PMID: 96704

Incremental intravenous nitroglycerin for control of afterload during anesthesia in patients undergoing myocardial revascularization

K B Stengert et al. Anaesthesist. 1978 May.

Abstract

In 25 patients undergoing coronary artery bypass grafting hemodynamic measurements (including values obtained with Swan-Ganz catheterization in 21 of the patients) were made before and after administering a bolus injection of 64 or 96 mcg of nitroglycerin to relieve intraoperative hypertension. This pharmacological agent reduced afterload and preload without raising heart rate. The effect was apparent within 1-3 min and lasted 5-10 min. Untoward hypotension was not encountered in any instance. This intervention appears to be a safe approach to the treatment of intraoperative hypertension in patients with coronary artery disease.

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