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. 1976 Jul 16;58(3):137-48.
doi: 10.1007/BF00496021.

Studies on the biological effects of deuteriated organic compounds. I. Antifungal activity of perdeuteriated fatty acids on dermatophytes in vitro

N D Nguyên, J Vincent

Studies on the biological effects of deuteriated organic compounds. I. Antifungal activity of perdeuteriated fatty acids on dermatophytes in vitro

N D Nguyên et al. Mycopathologia. .

Abstract

The antifugal activity of some perdeuteriated fatty acids, with normal chain 11 to 18 carbon atoms, was investigated on common dermatophytes Epidermophyton floccosum, Microsporum canis, Trichophyton mentagrophytes and T. rubrum under in vitro conditions. These studies were performed by dilution technique and with respiratory measurements, Perdeuteriation of some fatty acids increases their inhibitory effect on the dermatophyte growth. Perdeuteriated n-hendecanoic acid proved to be the most active of the substances tested. Possible mechanisms behind the enhanced antifungal activity due to the perdeuteriation of fatty acids are discussed.

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