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Clinical Trial
. 1998 Jul;51(1):307-9.
doi: 10.1212/wnl.51.1.307.

A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine

L C Newman  1 , R B Lipton, C L Lay, S Solomon
Affiliations
Clinical Trial

A pilot study of oral sumatriptan as intermittent prophylaxis of menstruation-related migraine

L C Newman et al. Neurology. 1998 Jul.

Abstract

Headaches associated with menstruation are often resistant to abortive and preventative medications. We performed an open-label study in 20 female migraineurs, employing oral sumatriptan perimenstrually as short-term prophylaxis of menstrual migraine. In 126 sumatriptan-treated cycles, headache was absent in 52.4% and reduced in severity by 50% or greater in 42%. Breakthrough headaches were rare and significantly reduced in severity compared with baseline headaches.

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