doi: 10.1016/s0167-4838(98)00061-2.
Interaction of phosphonomethyl analog of dihydroxyacetone phosphate with rabbit muscle aldolase
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- PMID: 9675245
- DOI: 10.1016/s0167-4838(98)00061-2
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Interaction of phosphonomethyl analog of dihydroxyacetone phosphate with rabbit muscle aldolase
Biochim Biophys Acta.
.
Abstract
Aldolase presents the same binding affinity for dihydroxyacetone phosphate and its phosphonomethyl analog, but the partition coefficient between the intermediates from the Michaelis complex to the eneamine is different. The effects of the structural modification of the triose phosphate substrate on the interaction with rabbit muscle aldolase are discussed in connection with the mechanistic pathway and the three-dimensional structure of the enzyme.
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