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Review
. 1998 Jul;27(1):23-7.
doi: 10.1086/514620.

The pharmacodynamics of aminoglycosides

M K Lacy  1 , D P Nicolau, C H Nightingale, R Quintiliani
Affiliations
Review

The pharmacodynamics of aminoglycosides

M K Lacy et al. Clin Infect Dis. 1998 Jul.

Abstract

Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity, established the foundation for once-daily aminoglycoside dosing regimens. This new approach to aminoglycoside dosing appears to be safe, efficacious, and cost-effective, resulting in its increasing popularity in clinical practice.

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