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. 1976 Sep;152(4):565-7.
doi: 10.3181/00379727-152-39441.

Direct stimulation of renin release by calcium

D S Chen, A M Poisner

Direct stimulation of renin release by calcium

D S Chen et al. Proc Soc Exp Biol Med. 1976 Sep.

Abstract

Calcium directly stimulates renin release from rat kidney slices previously treated with calcium-free medium. The stimulant effect of calcium (0.5 or 6.0 mM) is not seen without the period of calcium depletion. The stimulant effect of calcium is still present in sodium-free medium but is reduced when the incubation is performed at 20 degrees instead of 37 degrees. The results suggest that the underlying mechanism of renin release may be comparable to that of catecholamine release, involving calcium-dependent and energy-dependent steps.

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