Review
doi: 10.1002/(sici)1099-0895(199806)14:2<171::aid-dmr207>3.0.co;2-g.
Role of endothelin-1 in diabetes mellitus
Affiliations
- PMID: 9679669
- DOI: 10.1002/(sici)1099-0895(199806)14:2<171::aid-dmr207>3.0.co;2-g
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Review
Role of endothelin-1 in diabetes mellitus
Diabetes Metab Rev.
1998 Jun.
Abstract
Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the available data of the role of endothelin-1 in Type 1 and Type 2 diabetes mellitus and the development of diabetic complication.
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