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. 1998 Jun;24(6):626-30.
doi: 10.1007/s001340050627.

Acute amiodarone-induced lung toxicity

L Donaldson  1 , I S Grant, M R Naysmith, J S Thomas
Affiliations

Acute amiodarone-induced lung toxicity

L Donaldson et al. Intensive Care Med. 1998 Jun.

Abstract

Objective: To investigate any relationship between the pathological features of amiodarone-induced pulmonary toxicity (APT) and clinical use of amiodarone in patients dying from acute respiratory distress syndrome (ARDS).

Design: Retrospective study. Review of clinical and pathological findings of patients dying from ARDS.

Setting: Intensive Care Unit (ICU) and Pathology Department of University hospital.

Subjects: Ten patients with clinical diagnosis of ARDS, who died in ICU and underwent post mortem examination.

Interventions: Case note review of clinical details; independent review of histological specimens.

Measurement and results: Over a 3-year period, ten patients underwent post mortem examination, of whom seven had received amiodarone. Three patients who received longer than 48 h of amiodarone had histological changes of widespread lipoid pneumonia, a recognised pattern of APT.

Conclusions: Acute amiodarone pulmonary toxicity is a definite pathological entity in ICU patients. High oxygen concentrations may be a risk factor, while pre-existing pathology, e. g. ARDS, may mask its development. Amiodarone should be used with caution in this group of patients.

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Comment in

  • Atrial tachyarrhythmia after cardiac surgery.
    Mayr A, Knotzer H, Mutz N, Hasibeder W. Mayr A, et al. Intensive Care Med. 1999 Feb;25(2):242-3. doi: 10.1007/s001340050827. Intensive Care Med. 1999. PMID: 10193563 No abstract available.

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