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. 1976 Oct 15;194(4262):334-5.
doi: 10.1126/science.968486.

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza

P Palese, M B Ritchey, J L Schulman, E D Kilbourne

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza

P Palese et al. Science. .

Abstract

Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent. A/New Jersey/11/76, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.

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