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. 1998 Jul 31;281(5377):706-9.
doi: 10.1126/science.281.5377.706.

Pioneer axon guidance by UNC-129, a C. elegans TGF-beta

A Colavita  1 , S Krishna, H Zheng, R W Padgett, J G Culotti
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Pioneer axon guidance by UNC-129, a C. elegans TGF-beta

A Colavita et al. Science. .

Abstract

The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

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