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Review
. 1998 Jun;8(3):425-30.
doi: 10.1016/s0959-4388(98)80071-8.

Huntingtin: a single bait hooks many species

J F Gusella  1 , M E MacDonald
Affiliations
Review

Huntingtin: a single bait hooks many species

J F Gusella et al. Curr Opin Neurobiol. 1998 Jun.

Abstract

Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent protein trapping to identify huntingtin interactors now reveals that many different prey fall victim to huntingtin bait.

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