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. 1998 Aug;42(8):2103-5.
doi: 10.1128/AAC.42.8.2103.

Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae

D L Trees  1 , A L Sandul, W L Whittington, J S Knapp
Affiliations

Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae

D L Trees et al. Antimicrob Agents Chemother. 1998 Aug.

Abstract

Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87-->Ile and Glu-91-->Gly mutations and the Gly-85-->Cys and Arg116-->Leu mutations) the MICs of ciprofloxacin (8.0 to 64.0 microg/ml) were higher than those for the isolate containing the single ParC mutation (Arg-116-->Leu; MIC, 1.0 microg/ml).

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References

    1. Belland R J, Morrison S G, Ison C, Huang W M. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol Microbiol. 1994;14:371–380. - PubMed
    1. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. Morbid Mortal Weekly Rep. 1993;42(14):4–5. - PubMed
    1. Corkill J E, Percival A, Lind M. Reduced uptake of ciprofloxacin in a resistant strain of Neisseria gonorrhoeae and transformation of resistance to other strains. J Antimicrob Chemother. 1991;28:601–604. - PubMed
    1. Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y. DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1995;29:561–563. - PMC - PubMed
    1. Deguchi T, Yasuda M, Nakano M, Ozeki S, Ezaki T, Maeda S-I, Saito I, Kawada Y. Rapid detection of point mutations of the Neisseria gonorrhoeae gyrA gene associated with decreased susceptibilities to quinolones. J Clin Microbiol. 1996;34:2255–2258. - PMC - PubMed

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