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Comparative Study
. 1978 Apr;13(2):283-90.

Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability

R R Griffiths, J V Brady, J D Snell
  • PMID: 96878
Comparative Study

Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability

R R Griffiths et al. Biol Psychiatry. 1978 Apr.

Abstract

A quantitative ratio measure was developed which permitted comparisons between the reinforcing and anorectic potency of eight phenylethylamine anorectics and cocaine in laboratory baboons. The ordering of these compounds based upon this ratio bears a reasonable correspondence to clinical drug evaluations. The measure may provide information for preclinical evaluation of relative abuse potential of anorectic drugs.

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