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Comparative Study
. 1998 Apr;17(2):236-43.
doi: 10.1109/42.700735.

Generalized linear least squares method for fast generation of myocardial blood flow parametric images with N-13 ammonia PET

K Chen  1 , M Lawson, E Reiman, A Cooper, D Feng, S C Huang, D Bandy, D Ho, L S Yun, A Palant
Affiliations
Comparative Study

Generalized linear least squares method for fast generation of myocardial blood flow parametric images with N-13 ammonia PET

K Chen et al. IEEE Trans Med Imaging. 1998 Apr.

Abstract

In this paper, we developed and tested strategies for estimating myocardial blood flow (MBF) and generating MBF parametric images using positron emission tomography (PET), N-13 ammonia, and the generalized linear least square (GLLS) method. GLLS was generalized to the general linear compartment model, modified for the correction of spillover, validated using simulated N-13 ammonia data, and examined using PET data from several patient studies. In comparison to the standard model-fitting procedure, the GLLS method provided similar accuracy and superior computational speed.

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