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. 1998 Aug 4;95(16):9061-3.
doi: 10.1073/pnas.95.16.9061.

Aquaporin null phenotypes: the importance of classical physiology

P Agre  1
Affiliations

Aquaporin null phenotypes: the importance of classical physiology

P Agre. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Thin cryosections (1 μm) of rat kidney immunolabeled with anti-AQP1 and counterstained with peroxidase. (A) Cortex contains proximal tubules with abundant immunolabeling of the apical brush border (arrowhead) and basolateral plasma membranes with infoldings (arrows). Other nephron segments including distal-convoluted tubules (D) failed to label. (B) Inner medulla contains descending thin limbs that exhibit extensive immunolabeling of both apical (arrowhead) and basolateral (arrow) plasma membranes domains. Vascular structures, ascending thin limbs (∗), and collecting ducts (C) failed to label. ×650. Figure provided by Søren Nielsen, University of Aarhus, Denmark.
Figure 2
Figure 2
CAT mouse features microphthalmia and congenital cataracts resulting from a mutation in the gene encoding lens AQP0 (major intrinsic protein of lens). (A) Head of a 3-week-old CAT mouse, revealing the unusually small eye. (B) Lens from a normal 21-day-old mouse. (C) Lens from a 21-day-old CAT mouse is small and contains a dense opacity. Figure provided by Alan Shiels, Washington University, St. Louis, MO.
Figure 3
Figure 3
Morphology of transgenic Arabidopsis thaliana. Plant expressing antisense RNA to aquaporin PIP1b (Left) and control plant (Right). Except for a fivefold amplification of root arborization, the morphology of the antisense plant is equivalent to the control. Modified with permission (23). Figure provided by Ralf Kaldenhoff, University of Würzburg, Germany.
See this image and copyright information in PMC

Comment on

References

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