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Case Reports
. 1998 Jul-Aug;18(4):871-3.

Tramadol-warfarin interaction

J R Sabbe  1 , P J Sims, M H Sims
Affiliations
  • PMID: 9692666
Case Reports

Tramadol-warfarin interaction

J R Sabbe et al. Pharmacotherapy. 1998 Jul-Aug.

Abstract

A 61-year-old women receiving warfarin after mitral valve replacement experienced extensive ecchymoses after starting tramadol therapy. Laboratory values revealed critical elevations of prothrombin time and international normalized ratio. The patient's coagulation values returned to acceptable levels after discontinuing tramadol and temporarily stopping warfarin. The mechanism for this interaction is unknown. Practitioners should be aware of the possibility of such a interaction and exercise caution when tramadol is prescribed for a patient receiving warfarin.

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