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. 1998 Aug;9(8):1961-8.
doi: 10.1091/mbc.9.8.1961.

The membrane-based mechanism of cell motility in cochlear outer hair cells

G I Frolenkov  1 , M Atzori, F Kalinec, F Mammano, B Kachar
Affiliations
Free PMC article

The membrane-based mechanism of cell motility in cochlear outer hair cells

G I Frolenkov et al. Mol Biol Cell. 1998 Aug.
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
OHC electromotility in an external electric field.
Figure 2
Figure 2
OHC electromotility in whole-cell patch-clamp conditions.
Figure 3
Figure 3
Bending of the OHC in an external electric field
Figure 4
Figure 4
OHC electromotile force is sufficient to produce movement inside the organ of Corti.
Figure 5
Figure 5
OHC electromotility and intracellular pressure.
Figure 6
Figure 6
Effect of salicylate on the OHC electromotility.
Figure 7
Figure 7
Disruption of the OHC cytoskeleton with diamide does not affect electromotility
Figure 8
Figure 8
Electromotile mechanism requires only plasma membrane integrity.
Figure 9
Figure 9
Schematics of OHC force generation unit.
See this image and copyright information in PMC

References

    1. Ashmore JF. A fast motile response in guinea pig outer hair cells: the cellular basis for the cochlear amplifier. J Physiol. 1987;388:323–347. - PMC - PubMed
    1. Ashmore JF, Kolston PJ. Hair cell based amplification in the cochlea. Curr Opin Neurobiol. 1994;4:503–508. - PubMed
    1. Becker PS, Cohen CM, Lux SE. The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin. J Biol Chem. 1986;261:4620–4628. - PubMed
    1. Bezanilla F, White MM. Gating currents associated with potassium channel activation. Nature. 1982;296:657–659. - PubMed
    1. Brownell WE. Outer hair cell electromotility and otoacoustic emissions. Ear Hear. 1990;11:82–92. - PMC - PubMed

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